A Coagulation Defect in Amyloidosis

The association of the presence of an abnormal serum protein fraction between P and y globulins in reticuloendothelial disease and lymphatic leukaemia is a Ml recognized phenomenon (Rundles et al., 1954; Buffa and Rappaport, 1957; Owen e* 1959). The combination of leukaemia and amyloidosis is also recognized, but he presence of a coagulation defect in amyloidosis must be relatively uncommon. CASE HISTORY A man aged 60 was first seen in another hospital in October 1958 with a four week history of Pain in the left hypochondrium and a feeling of fulness in the lower abdomen after meals. We had recently noted a swelling in the left upper quadrant. On examination, the liver and the sPleen were both enlarged, and lymph glands were palpable in both axillae.